WISHWISH was designed to study the cardiovascular and cognitive (thinking, memory) effects of high-dose soy-isoflavone supplementation in women. In this double-blinded, placebo-controlled trial, 350 postmenopausal women 45 to 92 years of age without diabetes and cardiovascular disease were randomized to 2 evenly divided daily doses of 25 g soy protein containing 91 mg aglycon isoflavone equivalents or to placebo for up to 3.5 years.

Funding Source

This study was supported by National Institutes of Health from the National Center for Complementary and Alternative Medicine, the Office of Dietary Supplements, and the Office of Research on Women’s Health. Solae LLC (St Louis, MO) provided the study products gratis.

Registered at clinicaltrials.gov under NCT00118846